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Procedural / Technique
cardiac
High-impact pattern

CPB Weaning — Separation From Cardiopulmonary Bypass

Checklist-driven transition from mechanical to native circulation: rewarm, ventilate, de-air, TOE, protamine, inotropy, trial off, decannulate.

CPB weaning is a deliberate, checklist-gated transition from mechanical to native circulation, gated by rewarming, ventilation, de-airing, TOE, hemostasis, inotropy, and a graded flow reduction before decannulation.

If you forget

HEADLINE: Run the WEAN checklist before touching pump flow — reheat ≥36 °C, vents off, TOE in, inotropes loaded, ABG/K+/Ca2+ correct, protamine ready.

Board trap
Examiner asks 'patient fails to wean, BP 80/50, wedge 25, what next?' — answer RV vs LV failure distinction, then TOE first, inotrope/vasopressor choice based on SVR, and never leave CPB with undiagnosed surgical problem.

Key numbers

  • ACT target ≥480 s on CPB
  • Protamine 0.8–1.0 × initial heparin dose (1.3 ratio → bleeding)
  • Rewarm to ≥36 °C core before weaning
  • Trial CPB flow 1–2 L/min before decannulation
  • VA-ECMO wean: 0.5–1 L/min q5–15 min rapid or q2–4 h standard
Reviewed Sep 24, 2026 for clinical accuracy by BoardsBridge Editorial Process

Uri Rozen, MD — Licensed Physician, Israel

Source guidelines: EACTS EACTA EBCP CPB Fulltext 2019 · EACTS EACTA EBCP CPB Fulltext 2019 · EACTS EACTA EBCP CPB Fulltext 2019 · EACTS EACTA EBCP CPB Fulltext 2019

Re-review cadence: 12 months from reviewed date.

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Related on BoardsBridge

Card ID: cpb-weaning · Path: aba.cardiac.cardiopulmonary-bypass.cpb-weaning

Educational reference only. Reviewed for clinical accuracy against current authoritative guidelines. Not a substitute for clinical judgment. See editorial process and the sitemap entry for this card.